Knee Surg Relat Res  
Efficacy of Taurolidine Irrigation in Primary Total Knee Arthroplasty
Young Ha Woo, MD, Ju Seon Jeong, MD, Ok Geol Kim, MD, and In Seung Lee, MD
Department of Orthopedic Surgery, Busan Bumin Hospital, Busan, Korea
Correspondence to: Ju Seon Jeong, MD
Department of Orthopedic Surgery, Bumin Hospital, 59 Mandeok-daero, Buk-gu, Busan 46555, Korea
Tel: +82-51-330-3082, Fax: +82-51-330-3075
Received: July 24, 2017; Revised: October 9, 2017; Accepted: October 30, 2017; Published online: March 19, 2018.
© Korean Knee Society. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis. The aim of this study was to evaluate the efficacy of taurolidine irrigation in primary total knee arthroplasty (TKA).
Materials and Methods: All patients who underwent TKA at our institute from January 2015 to March 2017 were eligible. There were 300 patients in the taurolidine irrigation group and 300 patients in the control group. The patients in the taurolidine irrigation group were irrigated after implantation with a mix of 250 mL of taurolidine and 750 mL of normal saline. The patients in the control group were not irrigated after implantation. We compared postoperative C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and infection rate between groups.
Results: The taurolidine irrigation group had a significantly lower CRP (5.39 mg/dL vs. 7.55 mg/dL; p<0.001) and ESR (53.21 mm/hr vs. 58.74 mm/hr; p=0.003) on postoperative day 3 after TKA, as compared with the control group. However, there was no difference between the two groups on postoperative days 6, 13, and 20. Periprosthetic joint infection occurred in one patient in the taurolidine irrigation group.
Conclusions: We believe that it is not necessary to use taurolidine for patients who undergo primary TKA.
Keywords: Knee, Infection, Arthroplasty, Taurolidine, C-reactive protein


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