Knee Surg Relat Res  
Infrapatellar Fat Pad-Derived Stem Cell-Based Regenerative Strategies in Orthopedic Surgery
Pinar Yilgor Huri, PhD1, Seren Hamsici, MSc1, Emre Ergene, MSc1,2, Gazi Huri, MD3, and Mahmut Nedim Doral, MD3
1Department of Biomedical Engineering, Ankara University Faculty of Engineering, Ankara; 2Ankara University Biotechnology Institute, Ankara; 3Department of Orthopedics and Traumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Correspondence to: Gazi Huri, MD
Department of Orthopedics and Traumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Tel: +90-312-305-1209, Fax: +90-312-305-5000
E-mail: gazihuri@hacettepe.edu.tr
Received: August 4, 2017; Revised: December 22, 2017; Accepted: January 5, 2018; Published online: March 19, 2018.
© Korean Knee Society. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Infrapatellar fat pad is a densely vascularized and innervated extrasynovial tissue that fills the anterior knee compartment. It plays a role in knee biomechanics as well as constitutes a source of stem cells for regeneration after knee injury. Infrapatellar fat pad-derived stem cells (IPFP-ASCs) possess enhanced and age-independent differentiation capacity as compared to other stem cells, which makes them a very promising candidate in stem cell-based regenerative therapy. The aims of this review are to outline the latest advances and potential trends in using IPFP-ASCs and to emphasize the advantages over other sources of stem cells for applications in orthopedic surgery.
Keywords: Knee, Fat pad, Stem cell


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